TEST QUESTION: Ibuprofen & Heart Attacks

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TODAY’S TEST QUESTION:


CORRECT ANSWER:

B) They should not take NSAIDs

MORE INFO:

  • FDA has a warning statement that NSAIDs (such as ibuprofen) can actually increase the risk to have a myocardial infarction.

  • Asa is the exception and is actually recommended in MI hx to help prevent. NSAIDs elevate blood pressure and can cause heart failure (1).

  • Even short term use can create problems. Naproxen is an NSAID that also carries a risk for MI. (2)

  • Risk is highest in first few weeks of using & with higher doses (2).

  • NSAIDS cause a “relatively selective reduction in prostacyclin activity” and this can “could predispose to endothelial injury” (3), but there could be other factors “including effects on blood pressure, renal function, endothelial cells, and nitric oxide production ” that contribute -(3-Solomon, 2017).

  • Endothelial injury -cells damaged in the lining of blood vessels

  • References:
    1) Harvard Health Publishing
    2) Medscape All Nsaids linked to Increased MI risk
    3) Solomon, D. (2017) “COX-2 Selective Inhibitors: Adverse Cardiovascular effects”-Up to Date

DISCLAIMER: The information posted is not intended to be medical advice. This is for educational purposes only. This information is intended for medical professionals & students. Check with your primary care provider if you have any questions regarding your health. This is not intended to guide in medical decisions or treatment in any way. As always, medical professionals should call the on call provider if any clarifications are needed. This is not intended to guide or direct medical decisions, treatment choices, and or interventions. State and hospital protocols should always be followed accordingly. Med Made Ez (MME) disclaims any liability for the decisions you make based on this information.

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